Hybrid Computing Service

Registration

Please register first with your email address and a password of your choice. Optionally, you may register a key for a second authentication factor for extra security after registration (Smartphone, Yubikey, etc - see FAQ).

The storage of the email address only serves the following purposes (see data protection policy), for example, account verification, notification of results, password reset. In no case do we use your data to contact you by other than the described purposes, and in no case do we connect your data to other data sources or provide it to third parties, explicitly we do not connect your user account data to the access logfile from our website.

EagleImp-Web

Genotype phasing and imputation for your GWAS study data is simple:

1. Select your GWAS data in vcf.gz or bcf format from your hard drive for a client-side pre-check of the input format. This must include one file per chromosome (files for chromosomes 1 to 24 are allowed) in vcf.gz or bcf format. Instructions for preparing the vcf.gz or bcf files can be found here: https://imputationserver.readthedocs.io/en/latest/prepare-your-data/
2. Select the desired options for phasing and/or imputation. Behind each selection field you find a question mark and/or an information symbol about the meaning of the selected option.
3. Read our GDPR-compliant data protection policy and tick that you agree with our data policy. You can then start the phasing and/or imputation job. Do not leave the site until the data upload is complete! Once the calculation is completed, you will receive a notification email and see your results in the "Jobs" section.

EagleImp-Web

GWAIS-Web

Starting a GWAIS (genome-wide association interaction studies) job for epistasis detection is equally simple:

1. Your case/control genotype data must be in PLINK’s bed/bim/fam format. Select the file triple on your hard drive and a pre-flight check is automatically executed.
2. Select the desired options for your interaction test. Use the button with the question mark to get additional information about each option. It is mandatory to select at least one test method (e.g. logistic regression). You will immediately see a runtime estimation for your job.
3. Read our GDPR-compliant data protection policy and tick that you agree with our data policy. You can then start the epistasis detection job. Do not leave the site until the data upload is complete! Once the calculation is completed, you will receive a notification email and see your results in the "Jobs" section.

GWAIS-Web

PIA-S/M

PIA enables a new state-of-the-art accuracy in predicting peptide presentation by HLA-II proteins in vivo.

1. You can choose your input files from four different input types: VCF, Proteome, Genetic table, input table.
2. Select PIA options and model type. Use the question mark for detailed information on each option.
3. Read our GDPR-compliant data protection policy and tick that you agree with our data policy. Then start your PIA job. Do not leave the site until the data upload is complete! Once the calculation is completed, you will receive a notification email and see your results in the "Jobs" section.

PIA-S/M

2 Factor Authentication (2FA)

As the genetic data you upload may be sensitive data, and your analysis results are worth to be protected from unauthorized access, you already secure your account with a strong password. For additional security though, our web service offers 2-factor authentication (2FA) to protect your account.

Important note: Once you’ve activated 2FA it is not possible to login without your key anymore! And once you lose your key, you will be irreversible locked out of your account. It is therefore possible to register more than one key as a fallback to regain your account after one key is lost.

With these three easy steps you enable 2FA and register your smartphone or USB key dongle as additional security factor for your user login:

1. After login go to “Two-factor authentication” in the account settings and click on "Register a new security key", type in your login password and a name (identifier) for your new key and hit “Register”.
2. The Webauthn API will automatically guide you through the registration process. You decide whether to register your smartphone or tablet, or a USB key dongle.
   1. In the case of your smartphone, you need to scan a QR code with your device to connect with the device and register your key.
   2. In the case of a USB key dongle, you need to insert it into your computer and usually touch it.
3. The key is now registered with your account and 2FA is activated. Each time you want to login now, you will be asked in addition to your password to either unlock the login with your smartphone or tablet, or to insert and touch your USB key dongle.

The images below show the registration process of a smartphone with the Webauthn API.

1) Register new security key

2) Create a passkey

3) Scan the QR code